Endocrine Abstracts

In addition to their documented impact on the cardiovascular system, polyunsaturated fatty acids (PUFAs) have also been shown to modulate steroidogenesis. However, the mechanistic nature of PUFA action on steroid synthesis remains unknown. PUFAs are recognised modulators of cholesterol trafficking. Liver X receptor (LXR) is a known cholesterol sensor that regulates a range of genes involved in cholesterol metabolism including Steroidogenic acute regulatory protein (StAR) which...